**When two processes are strongly coupled, you cannot treat one without affecting the other.**
Identify all significant couplings before prescribing.
The gut-brain axis, liver-hormone axis, and cardiac-autonomic-immune axis are documented regulatory couplings in which the dynamical state of one system directly modifies the attractor landscape of the other.
A prescription aimed at the nervous system that ignores a highly inflamed gut microbiome will be partially undone by continuous enteric inflammatory signalling.
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